|
|
testosterone + NAD+ <=> 4-androstene-3,17-dione + NADH + H+
|
1.1.1.112
indanol dehydrogenase
1.1.1.210
3beta(or 20alpha)-hydroxysteroid dehydrogenase
1.1.1.239
3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
1.1.1.357
3alpha-hydroxysteroid 3-dehydrogenase
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
1.1.1.62
17beta-estradiol 17-dehydrogenase
1.1.1.64
testosterone 17beta-dehydrogenase (NADP+)
|
–
–
–
–
–
–
–
|
BK
|
|
BRENDA:
BR29275
KEGG:
R01836
MetaCyc:
1.1.1.51-RXN_WOP;
TESTOSTERONE-17-BETA-DEHYDROGENASE-RXN
SABIO-RK:
1915
|
|
|
|
testosterone + NADP+ <=> 4-androstene-3,17-dione + NADPH + H+
|
1.1.1.146
11beta-hydroxysteroid dehydrogenase
1.1.1.148
estradiol 17alpha-dehydrogenase
1.1.1.184
carbonyl reductase (NADPH)
1.1.1.2
alcohol dehydrogenase (NADP+)
1.1.1.209
3(or 17)alpha-hydroxysteroid dehydrogenase
1.1.1.213
3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
1.1.1.239
3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
1.1.1.62
17beta-estradiol 17-dehydrogenase
1.1.1.64
testosterone 17beta-dehydrogenase (NADP+)
|
–
–
–
–
–
–
–
–
–
–
–
|
BMK
|
|
BRENDA:
BR29315;
BS438469
KEGG:
R01838
MetaCyc:
1.1.1.51-RXN;
1.1.1.64-RXN
SABIO-RK:
1917
|
|
|
|
4-androstene-3,17-dione + O2 + reduced_acceptor <=> testololactone + H2O + acceptor
|
1.14.99.12
androst-4-ene-3,17-dione monooxygenase
|
–
|
K
|
|
BRENDA:
BR40394;
BS375044
KEGG:
R01833
MetaCyc:
1.14.99.12-RXN
|
|
|
|
4-androstene-3,17-dione + NADPH + H+ + O2 <=> testololactone + NADP+ + H2O
|
1.14.13.54
ketosteroid monooxygenase
1.14.99.12
androst-4-ene-3,17-dione monooxygenase
|
–
–
|
|
|
BRENDA:
BR49816
KEGG:
R08205
MetaCyc:
RXN-12713
|
|
|
|
17alpha-hydroxyprogesterone + NADPH + O2 <=> 4-androstene-3,17-dione + acetate + NADP+ + H2O
|
1.14.13.54
ketosteroid monooxygenase
|
–
|
|
|
BRENDA:
BR49817
KEGG:
R08206
MetaCyc:
RXN-7819
|
|
|
|
5-androstene-3,17-dione <=> 4-androstene-3,17-dione
|
2.5.1.18
glutathione transferase
5.3.3.1
steroid Delta-isomerase
|
–
–
|
MK
|
|
BRENDA:
BS1076
KEGG:
R09955
MetaCyc:
RXN66-362
SABIO-RK:
7930
|
|
|
|
5beta-androstane-3,17-dione + NADP+ <=> 4-androstene-3,17-dione + NADPH + H+
|
1.3.1
1.3.1.3
Delta4-3-oxosteroid 5beta-reductase
|
–
–
|
K
|
|
BRENDA:
BS258364
KEGG:
R01835
MetaCyc:
RXN-16513
SABIO-RK:
10858
|
|
|
|
4-androstene-3,17-dione + acceptor <=> 1,4-androstadiene-3,17-dione + reduced_acceptor
|
1.3.99.4
3-oxosteroid 1-dehydrogenase
|
–
|
BMK
|
|
BRENDA:
BS258852
KEGG:
R09884
MetaCyc:
RXN-12714
|
|
|
|
4-androstene-3,17-dione + reduced_ferredoxin_[iron-sulfur]_cluster + O2 + H+ <=> 1alpha-hydroxyandrostenedione + oxidized_ferredoxin + H2O
|
1.14.15.19
C-19 steroid 1alpha-hydroxylase
|
–
|
|
|
BRENDA:
BS437020
MetaCyc:
RXN-17521
|
|
|
|
17alpha-hydroxyprogesterone + reduced_flavodoxin + O2 <=> 4-androstene-3,17-dione + acetate + flavin + H2O
|
1.14.14.32
17alpha-hydroxyprogesterone deacetylase
|
–
|
BK
|
|
BRENDA:
BR362
KEGG:
R08518
|
|
|
|
4-androstene-3,17-dione + 3 O2 + 3 reduced_flavodoxin <=> estrone + formate + 4 H2O + 3 flavin
|
1.14.14.14
aromatase
|
–
|
|
|
BRENDA:
BR50746
KEGG:
R10515
|
|
|
|
4-androstene-3,17-dione + O2 + reduced_flavodoxin <=> 19-hydroxyandrost-4-ene-3,17-dione + H2O + flavin
|
1.14.14.14
aromatase
|
–
|
K
|
|
BRENDA:
BR50747;
BS425925
KEGG:
R01840
|
|
|
|
4-androstene-3,17-dione + reduced_ferredoxin + O2 <=> 11beta-hydroxyandrost-4-ene-3,17-dione + oxidized_ferredoxin + H2O
|
1.14.15.4
steroid 11beta-monooxygenase
|
–
|
K
|
|
BRENDA:
BS186775
KEGG:
R02725
|
|
|
|
dehydroepiandrosterone + NAD+ <=> 4-androstene-3,17-dione + NADH + H+
|
1.1.1.145
3beta-hydroxy-Delta5-steroid dehydrogenase
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
5.3.3.1
steroid Delta-isomerase
|
–
–
–
|
K
|
|
BRENDA:
BS403792
KEGG:
R01837
|
|
|
|
5alpha-androstane-3,17-dione + acceptor <=> 4-androstene-3,17-dione + reduced_acceptor
|
1.3.99.5
3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)
|
–
|
MK
|
|
KEGG:
R01834
MetaCyc:
RXN-12124
|
|
|
|
Epitestosterone + NADP+ <=> 4-androstene-3,17-dione + NADPH
|
1.1.1.148
estradiol 17alpha-dehydrogenase
1.1.1.209
3(or 17)alpha-hydroxysteroid dehydrogenase
1.1.1.62
17beta-estradiol 17-dehydrogenase
|
–
–
–
|
|
|
BRENDA:
BS187271
SABIO-RK:
12600
|
|
|
|
Epitestosterone + NAD+ <=> 4-androstene-3,17-dione + NADH + H+
|
1.1.1.209
3(or 17)alpha-hydroxysteroid dehydrogenase
|
–
|
|
|
BRENDA:
BS187691-a
SABIO-RK:
13081
|
|
|
|
4-androstene-3,17-dione + NADPH + H+ <=> dehydroepiandrosterone + NADP+
|
1.1.1.145
3beta-hydroxy-Delta5-steroid dehydrogenase
|
–
|
|
|
BRENDA:
BS257049
SABIO-RK:
1918
|
|
|
|
4-androstene-3,17-dione + NADH + H+ <=> 4-androsten-3alpha-ol-17-one + NAD+
|
1.1.1.213
3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
|
–
–
–
|
|
|
BRENDA:
BS395821
SABIO-RK:
11977
|
|
|
|
5alpha-androstane-3,17-dione + NADP+ <=> 4-androstene-3,17-dione + NADPH + H+
|
1.3.1.22
3-oxo-5alpha-steroid 4-dehydrogenase (NADP+)
|
–
|
K
|
|
KEGG:
R10242
SABIO-RK:
14506
|
|
|
|
4-androstene-3,17-dione + reduced_flavodoxin + O2 <=> 7alpha-hydroxy-4-androstene-3,17-dione + flavin + H2O
|
1.14.14.1
unspecific monooxygenase
|
–
|
K
|
|
KEGG:
R01842
|
|
|
|
Delta4-Dafachronic_acid <=> 4-androstene-3,17-dione
|
not assigned
|
–
|
K
|
|
KEGG:
R09919
|
|
|
|
17alpha-hydroxyprogesterone + reduced_[NADPH-hemoprotein_reductase] + O2 <=> 4-androstene-3,17-dione + acetate + oxidized_[NADPH-hemoprotein_reductase] + H2O + H+
|
1.14.14.32
17alpha-hydroxyprogesterone deacetylase
|
–
|
|
|
MetaCyc:
4.1.2.30-RXN
|
|
|
|
17-hydroxy-3-oxo-4-pregnane-20-carboxyl-CoA <=> 4-androstene-3,17-dione + propionyl-CoA
|
2.3.1
|
–
|
M
|
|
MetaCyc:
RXN-12745
|
|
|
|
4-androstene-3,17-dione + reduced_[NADPH-hemoprotein_reductase] + O2 <=> estrone + oxidized_[NADPH-hemoprotein_reductase] + H2O + formate + H+
|
1.14.14.14
aromatase
|
–
|
|
|
MetaCyc:
RXN-14746
|
|
|
|
23,24-bisnorcholesta-4-ene-22-oic_acid <=> 4-androstene-3,17-dione
|
not assigned
|
–
|
|
|
MetaCyc:
RXN-21462
|
|
|
|
4-androstene-3,17-dione + reduced_[NADPH-hemoprotein_reductase] + O2 <=> 19-hydroxyandrost-4-ene-3,17-dione + oxidized_[NADPH-hemoprotein_reductase] + H2O
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN66-344
|
|
|
|
4-androstene-3,17-dione + 3 O2 + 3 reduced_flavoproteins <=> estrone + formate + 4 H2O + 3 oxidized_flavoproteins
|
1.14.14.14
aromatase
|
–
|
|
|
BRENDA:
BS424657
|
|
|
|
4-androstene-3,17-dione + FAD <=> 1,4-androstadiene-3,17-dione + FADH2
|
1.3.99.4
3-oxosteroid 1-dehydrogenase
|
–
|
|
|
BRENDA:
BS424574
|
|
|
|
4-androstene-3,17-dione + 2,6-dichlorophenolindophenol <=> 1,4-androstadiene-3,17-dione + reduced_2,6-dichlorophenolindophenol
|
1.3.99.4
3-oxosteroid 1-dehydrogenase
|
–
|
|
|
BRENDA:
BS395820
|
|
|
|
17alpha-hydroxyprogesterone + reduced_acceptor + O2 <=> dehydroepiandrosterone + 4-androstene-3,17-dione + A + H2O
|
1.14.14.32
17alpha-hydroxyprogesterone deacetylase
|
–
|
|
|
BRENDA:
BS416054
|
|
|
|
4-androstene-3,17-dione + reduced_acceptor + O2 <=> testosterone + 14alpha-hydroxyandrost-4-ene-3,17-dione + 11alpha-hydroxyandrost-4-ene-3,17-dione + 15beta-hydroxytestosterone + 11alpha-hydroxytestosterone + 15alpha-hydroxytestosterone + A + H2O
|
1.14.99.12
androst-4-ene-3,17-dione monooxygenase
|
–
|
|
|
BRENDA:
BS443053
|
|
|
|
4-androstene-3,17-dione + reduced_acceptor + O2 <=> testosterone + 11beta-hydroxyandrost-4-ene-3,17-dione + testololactone + A + H2O
|
1.14.99.12
androst-4-ene-3,17-dione monooxygenase
|
–
|
|
|
BRENDA:
BS443052
|
|
|
|
4-androstene-3,17-dione + reduced_ferredoxin + O2 <=> 15beta-hydroxyandrost-4-en-3,17-dione + oxidized_ferredoxin + H2O
|
1.14.15.8
steroid 15beta-monooxygenase
|
–
|
|
|
BRENDA:
BS442888
|
|
|
|
4-androstene-3,17-dione + reduced_ferredoxin + O2 <=> 19-hydroxy-4-androstene-3,17-dione + oxidized_ferredoxin + H2O
|
1.14.15.4
steroid 11beta-monooxygenase
|
–
|
|
|
BRENDA:
BS186776
|
|
|
|
4-androstene-3,17-dione + reduced_acceptor + O2 <=> 14alpha-hydroxyandrost-4-ene-3,17-dione + 6beta-hydroxytestosterone + A + H2O
|
1.14.99.12
androst-4-ene-3,17-dione monooxygenase
|
–
|
|
|
BRENDA:
BS443051
|
|
|
|
4-androstene-3,17-dione + reduced_acceptor + O2 <=> 14alpha-hydroxyandrost-4-ene-3,17-dione + 14alpha,17beta-dihydroxyandrost-4-en-3-one + 7alpha,17beta-dihydroxyandrost-4-en-3-one + A + H2O
|
1.14.99.12
androst-4-ene-3,17-dione monooxygenase
|
–
|
|
|
BRENDA:
BS443050
|
|
|
|
4-androstene-3,17-dione + NADH + O2 <=> 9alpha-hydroxy-4-androstene-3,17-dione + NAD+ + H2O
|
1.14.15.30
3-ketosteroid 9alpha-monooxygenase
1.14.99.24
steroid 9alpha-monooxygenase
|
–
–
|
|
|
BRENDA:
BS287931
|
|
|
|
testosterone + NADH + H+ <=> 4-androstene-3,17-dione + NAD+
|
1.1.1.357
3alpha-hydroxysteroid 3-dehydrogenase
|
–
|
|
|
BRENDA:
BS425050-a
|
|
|
|
allopregnanolone + reduced_flavodoxin + O2 <=> 4-androstene-3,17-dione + acetate + flavin + H2O
|
1.14.14.32
17alpha-hydroxyprogesterone deacetylase
|
–
|
|
|
BRENDA:
BS437006
|
|
|
|
progesterone + 2 reduced_acceptor + 2 O2 <=> 4-androstene-3,17-dione + acetate + 2 A + 2 H2O
|
1.14.14.19
steroid 17alpha-monooxygenase
|
–
|
|
|
BRENDA:
BS407298
|
|
|
|
4-androstene-3,17-dione + 2 reduced_ferredoxin_[iron-sulfur]_cluster + 2 H+ + O2 <=> 9alpha-hydroxy-4-androstene-3,17-dione + 2 oxidized_ferredoxin + H2O
|
1.14.15.30
3-ketosteroid 9alpha-monooxygenase
|
–
|
|
|
BRENDA:
BS418289
|
|
|
|
4-androstene-3,17-dione + NADPH + H+ <=> 5alpha-Androstan-3,17-dione + NADP+
|
1.3.1.22
3-oxo-5alpha-steroid 4-dehydrogenase (NADP+)
|
–
|
|
|
BRENDA:
BS260960
|
|
|
|
testosterone + NADP+ <=> 4-androstene-3,17-dione + NADH + H+
|
1.1.1.112
indanol dehydrogenase
1.1.1.62
17beta-estradiol 17-dehydrogenase
|
–
–
|
|
|
BRENDA:
BS187030
|
|
|
|
4-androstene-3,17-dione + NADPH + H+ <=> androsterone + NADP+
|
1.1.1.209
3(or 17)alpha-hydroxysteroid dehydrogenase
|
–
|
|
|
BRENDA:
BS394696
|
|
|
|
progesterone + 2 NADPH + 2 H+ + 2 O2 <=> 4-androstene-3,17-dione + acetate + 2 NADP+ + 2 H2O
|
1.14.14.19
steroid 17alpha-monooxygenase
|
–
|
|
|
BRENDA:
BS407302
|
|
|
|
4-androstene-3,17-dione + NADPH <=> 4-androsten-3alpha-ol-17-one + NADP+
|
1.1.1.209
3(or 17)alpha-hydroxysteroid dehydrogenase
|
–
|
|
|
BRENDA:
BS187719
|
|
|
|
4-androstene-3,17-dione + NADPH + H+ + O2 <=> 7alpha-hydroxy-4-androstene-3,17-dione + NADP+ + H2O
|
1.14.14.29
25/26-hydroxycholesterol 7alpha-hydroxylase
|
–
|
|
|
BRENDA:
BS375865
|
|
|
|
4-androstene-3,17-dione + NADPH <=> 5beta-androstan-3,15-dione + NADP+
|
1.3.1.3
Delta4-3-oxosteroid 5beta-reductase
|
–
|
|
|
BRENDA:
BS387419
|
|
|
|
testosterone + NADPH + H+ <=> 4-androstene-3,17-dione + NADP+
|
1.1.1.357
3alpha-hydroxysteroid 3-dehydrogenase
|
–
|
|
|
BRENDA:
BS425050
|
|
|
|
5beta-androstane-3,17-dione + acceptor <=> 4-androstene-3,17-dione + reduced_acceptor
|
1.3.99.6
3-oxo-5beta-steroid 4-dehydrogenase
|
–
|
|
|
BRENDA:
BS258881
|
|
|
|
4-androstene-3,17-dione + phenazine_methosulfate <=> 1,4-androstadiene-3,17-dione + reduced_phenazine_methosulfate
|
1.3.99.4
3-oxosteroid 1-dehydrogenase
|
–
|
|
|
BRENDA:
BS395822
|
|
|
|
5alpha-androstane-3,17-dione + N,N,N'',N''-tetramethyl-1,4-phenylendiamine <=> 4-androstene-3,17-dione + reduced_N,N,N'',N''-tetramethyl-1,4-phenylendiamine
|
1.3.99.5
3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)
|
–
|
|
|
BRENDA:
BS451556
|
|
|
|
dehydroepiandrosterone <=> 4-androstene-3,17-dione
|
5.3.3.1
steroid Delta-isomerase
|
–
|
|
|
BRENDA:
BS428561
|
|
|
|
16-dehydroprogesterone + NADPH + O2 <=> 4-androstene-3,17-dione
|
1.14.99.4
progesterone monooxygenase
|
–
|
|
|
BRENDA:
BS287911
|
|
|
|
4-androstene-3,17-dione + reduced_adrenodoxin + O2 <=> 15beta-hydroxyandrostene-3,17-dione + oxidized_ferredoxin + H2O
|
1.14.15.8
steroid 15beta-monooxygenase
|
–
|
|
|
BRENDA:
BS442887
|
|
|
|
4-androstene-3,17-dione + reduced_megaredoxin + O2 <=> 15beta-hydroxyandrostene-3,17-dione + oxidized_megaredoxin + H2O
|
1.14.15.8
steroid 15beta-monooxygenase
|
–
|
|
|
BRENDA:
BS403807
|
|
|
|
NADPH + 17alpha-hydroxyprogesterone <=> 4-androstene-3,17-dione + NADP+
|
1.14.14.19
steroid 17alpha-monooxygenase
|
–
|
|
|
SABIO-RK:
7635
|
|
|
|
H+ + 4-androstene-3,17-dione + NADPH + O2 <=> NADP+ + formate + estrone + H2O
|
1.14.14.1
unspecific monooxygenase
|
–
|
|
|
SABIO-RK:
9576
|
|